Bath Researchers Study How Cancer Cells Come Unstuck

�Scientists in the Department of Biology & Biochemistry at the University of Bath stimulate started a three year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.


Cancer affects one in three people at some point in their lives, with about cancer deaths being caused by the development of secondary tumours in early parts of the body. This research, funded by leading aesculapian charity Cancer Research UK, could help scientists better understand what causes cancer to spreading and english hawthorn suggest new ways it could be treated in the future.


Normal cells are held together by junctions on the cell surface, but in some cancers these junctions are lost. This makes the cancerous cells more likely to break off and spread head tumours to other parts of the body. Dr Andrew Chalmers and Dr Paul Whitley, both lecturers from the Department of Biology & Biochemistry, are studying how a chemical group of proteins called ESCRTs are involved in the loss of these junctions in kidney and bowel cells.


"ESCRTs are like the recycling units of the cell; they oversee the constant uptake, break down and replenishing of junctions on the cell surface," explained Dr Chalmers.


"In a cancer cadre where ESCRTs are discredited, the junctions may not be restored properly; this can cause cells to separate and migrate to form secondary tumours in other parts of the body.


"Previous studies have shown a link between ESCRTs and the loss of junctions in cells of fruit flies, so we want to see whether this is also true in humans."


During this trey year jut out, the researchers plan to block ESCRTs in cells grown in the science lab to watch the personal effects on the junctions. They will besides be looking at whether mutations of ESCRTs are more uncouth in sure types of cancer.


Dr Paul Whitley added: "This work should evidence us more than about the role of ESCRTs in cancer and provide possible new targets for therapy in the future."


BATH UNIVERSITY

Wessex House

Bath

BA2 7AY
http://www.bath.ac.uk



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Mp3 music: Bobby Orlando

Artist: Bobby Orlando: mp3 download    Genre(s):  Blues Electronic Country     Bobby Orlando's discography:      The Best of the musica 80s Vol 2    Year: 1987    Tracks: 12      The Best of the musica 80's Vol 5    Year:     Tracks: 13      The Best of the musica 80's Vol 4    Year:     Tracks: 12      The Best of the Best of the musica80s Vol 1    Year:     Tracks: 12 Producer Bobby Orlando became a legend in the '80s through a mass of disco music and Hi-NRG records released on his independent mark, O Records. The son of a Westchester, NY, school teacher, Orlando boxed true kO'd of high school and listened to Alice Cooper and T. Rex. He off down a greco-Roman medicine scholarship, instead performing Johnny Thunder-style guitar in teenager sparkle bands. Swept up by disco, Orlando engineered "Dancin'" by Todd Forester in 1977. The call featured the galloping sea bass part contrast developed by synth-phenom Giorgio Moroder, wHO Orlando strove to emulate throughout his life history. Orlando as well highly-developed a womb-to-tomb fascination with the studio beau idealistic of ABBA. In 1980, Orlando masterminded the 1st-class mail Lyn Todd album, before setting up O Records. The number one releases, "Just a Gigolo" by Barbie & the Kens and "Change of Life" by I Spy, made Billboard's dance chart. As disco died, Orlando unflinchingly overflowing the market place with beat-heavy blasts. Some, like Roni Griffith's "Desire" and "Take a Chance on Me" by Waterfront Home, became golf golf club hits. Also in 1980, Divine came to Orlando for his production expertness, and the mate unleashed a string of notoriously successful singles. Orlando so devised the Flirts, a figurehead trinity of revolving beauties to perform his songs. Orlando's Nunzio Brocheno Productions as well produced Lisa Lisa & Cult Jam and Full Force. This subway rage social movement was dubbed Hi-NRG and light-emitting diode Smash Hits writer and Pet Shop Boy Neil Tennant to seek out Orlando. Orlando launched the career of the British twosome, including an early rendering of "West End Girls." The Pet Shop Boys left for EMI and worldwide achiever. Hurt by the want of gratitude from his volume stable of artists, Orlando gentle phased out of his music empire. He returned to his law studies and finished a rule book called Darwin Destroyed, refuting the possibility of development. In the '90s, he began some other pronounce, Reputation Records.

Alejandra Guzman

   
Artist: Alejandra Guzman

   Genre(s): 
Rock
   Dance
   Other
   Pop
   

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Discography:


   
 Indeleble

   Year: 2006   
Tracks: 11


   
 Lipstick

   Year: 2004   
Tracks: 11


   
 En vivo

   Year: 2003   
Tracks: 20


   
 Agresivamente tuya

   Year: 2002   
Tracks: 16


   
 Soy

   Year: 2001   
Tracks: 9


   
 Serie Platino: 20 Exitos

   Year: 2000   
Tracks: 19


   
 Algo Natural

   Year: 1999   
Tracks: 14


   
 Eternamente Bella

   Year: 1997   
Tracks: 10


   
 Cambio De Piel

   Year: 1996   
Tracks: 10


   
 Enorme

   Year: 1994   
Tracks: 10


   
 Al Borde De La Locura

   Year: 1994   
Tracks: 14


   
 Libre

   Year: 1993   
Tracks: 11


   
 Flor De Papel

   Year: 1991   
Tracks: 10


   
 Dame tu amor

   Year: 1989   
Tracks: 8


   
 Bye mama

   Year: 1988   
Tracks: 10


   
 La Guzman [CASSETTE]

   Year:    
Tracks: 16

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Singer/actress Alejandra Guzman was born into a playing family, the girl of Mexican actress Silvia Pinal and Mexican rock star Enrique Guzman. Appropriately sufficiency for a famous person child, she made her first TV visual aspect when she was hardly two months old. She spent her childhood preparing to be a long-familiar performing creative person in her own veracious, tattle, terpsichore and traveling with her mom's theatrical company. Following her mother's wishes, she didn't pursue a perfoming calling in full until she ruined school; after she gradatory, the 17 year-old Guzman appeared in a production of Mame with her mother. From that day, she knew she wanted to be a singer.


Afterward teaming up with producer Miguel Blasco, Guzman recorded her debut album Pass Mama, which was number one in Mexico within years of its vent. She released albums nearly yearly afterwards her debut and enjoyed a big, enthusiastic fanbase throughout Latin America. Though Guzman encountered some personal problems in the mid and recent '90s, including a stay in rehab and a divorce, she brought her life history full circle in 1998 by coming into court onstage with her mother once more, this time in a production of Romany, and released her twelfth album Algo Natural in 1999.





Chris Rock