�Scientists in the Department of Biology & Biochemistry at the University of Bath stimulate started a three year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.
Cancer affects one in three people at some point in their lives, with about cancer deaths being caused by the development of secondary tumours in early parts of the body. This research, funded by leading aesculapian charity Cancer Research UK, could help scientists better understand what causes cancer to spreading and english hawthorn suggest new ways it could be treated in the future.
Normal cells are held together by junctions on the cell surface, but in some cancers these junctions are lost. This makes the cancerous cells more likely to break off and spread head tumours to other parts of the body. Dr Andrew Chalmers and Dr Paul Whitley, both lecturers from the Department of Biology & Biochemistry, are studying how a chemical group of proteins called ESCRTs are involved in the loss of these junctions in kidney and bowel cells.
"ESCRTs are like the recycling units of the cell; they oversee the constant uptake, break down and replenishing of junctions on the cell surface," explained Dr Chalmers.
"In a cancer cadre where ESCRTs are discredited, the junctions may not be restored properly; this can cause cells to separate and migrate to form secondary tumours in other parts of the body.
"Previous studies have shown a link between ESCRTs and the loss of junctions in cells of fruit flies, so we want to see whether this is also true in humans."
During this trey year jut out, the researchers plan to block ESCRTs in cells grown in the science lab to watch the personal effects on the junctions. They will besides be looking at whether mutations of ESCRTs are more uncouth in sure types of cancer.
Dr Paul Whitley added: "This work should evidence us more than about the role of ESCRTs in cancer and provide possible new targets for therapy in the future."
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